Dept. of Biochemistry, CLS, WHU
Xu Lab
RNA Splicing & Development, Diseases

Publications:

# : contribute equally, * : corresponding author.

  1. Ding Z, Meng YR, Fan YJ, Xu YZ*. (2022) Roles of minor spliceosome in intron recognition and the convergence with the better understood major spliceosome. WIREs RNA e1761.

  2. Gui XM#, Zhang P#, Wang D#, Ding Z#, Wu X, Shi JX, Shen QH, Xu YZ, Ma WB and Qiao YL*. (2022) Phytophthora effector PSR1 hijacks the host pre-mRNA splicing machinery to modulate small RNA biogenesis and plant immunity. Plant Cell, 34(9), 3443–3459.

  3. Tang P#, Yang Y#, Li G, Huang L, Wen M, Ruan W, Guo X, Zhang C, Zuo X, Luo D, Xu YZ, Fu XD*, & Zhou Y*. (2022) Alternative polyadenylation by sequential activation of distal and proximal PolyA sites. Nat Struct Mol Biol 29, 21–31.

  4. Zhang B#, Ding Z#, Li L, Xie LK, Fan YJ and Xu YZ* (2021) Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila. PLoS Genetics 17(11): e1009861.

  5. Pang TL, Ding Z, Liang SB, Li L, Zhang B, Zhang Y, Fan YJ and Xu YZ* (2021) Comprehensive identification and alternative splicing of microexons in Drosophila. Frontiers in Genetics 12: 642602.

  6. Li L, Ding Z, Pang TL, Zhang B, Li CH, Liang AM, Wang YR, Zhou Y, Fan YJ* and Xu YZ* (2020) Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila. Nature Communications 11(1):5608. Recommended in the focus of “From Brain to Behaviour”.

  7. Shao W, Ding Z, Zheng ZZ, Shen JJ, Shen YX, Pu J, Fan YJ, Query CC* and Xu YZ* (2020) Prp5–Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription. Nucleic Acids Research 48, 5799–5813. Selected as “Breakthrough Article”.

  8. Cheng L, Zhang Y, Zhang Y, Chen T, Xu YZ and Rong YS* (2020) Loss of the RNA trimethylguanosine cap is compatible with nuclear accumulation of spliceosomal snRNAs but not pre-mRNA splicing or snRNA processing during animal development. PLoS Genetics 16(10): e1009098.

  9. Zhu Y, Wu W, Shao W, Chen J, Shi X, Ma X, Xu YZ, Huang W and Huang J* (2020) SPLICING FACTOR1 is important in chloroplast development under cold stress. Plant Physiology 184(2): 973-987.

  10. Zheng ZZ, Sun X, Zhang B, Pu J, Jiang ZY, Li M, Fan YJ and Xu YZ* (2019) Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori. RNA Biology, 16: 809-820.

  11. Qiu C#, Zhang Y#, Fan YJ#, Pang TL, Su Y, Zhan S* and Xu YZ* (2019) HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. J Mol Cell Biol, 11: 170-181.

  12. Lv M, Yao Y, Li F, Xu L, Yang L, Gong Q, Xu YZ, Shi Y, Fan YJ*, Tang Y* (2019) Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila. Nucleic Acids Research, 47: 3142-3157.

  13. Tang Q#, Rodriguez-Santiago S#, Wang J, Pu J, Yuste A, Gupta V, Moldón A, Xu YZ* and Query CC* (2016) SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing. Genes & Development, 30: 2710-2723.

  14. Gao JL#, Fan YJ#, Wang XY#, Zhang Y, Pu J, Li L, Shao W, Zhan S, Hao J and Xu YZ*(2015) A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila. Genes & Development 29, 760-771, DOI: 10.1101/gad.258863.115.

  15. Qiu C, Liu WY* and Xu YZ* (2015) Fluorescence labeling of short RNA by oxidation at the 3'-end. Methods in Molecular Biology 1297, DOI 10.1007/978-1-4939-2562-9_8.

  16. Fan Y*, Gittis AH, Juge F, Qiu C, Xu YZ and Rabinow L* (2014) Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila. Genetics 197:1251-1265.

  17. Wang XY, Zheng ZZ, Song HS and Xu YZ* (2014) Conserved RNA cis-elements regulate alternative splicing of Lepidopteran doublesex. Insect Biochemistry and Molecular Biology 44, 1-11.

  18. Zhang ZM#, Yang F#, Zhang J, Tang Q, Li J, Gu J, Zhou J.*and Xu YZ* (2013) Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Reports 5, 1269-1278.

  19. Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query CC and Xu YZ*(2013) Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Research 41, 4660-4670.

  20. Shao W#, Zhao QY#, Wang XY, Xu XY, Li MW, Li X* and Xu YZ* (2012) Alternative splicing and trans-splicing events revealed by analysis of the Bombyx mori transcriptome. RNA 18, 1395-407.

  21. Shao W, Kim HS, Cao Y, Xu YZ* and Query CC* (2012) A U1–U2 snRNP interaction network during intron definition. Molecular and Cellular Biology 32, 470-478.